Mushroom Research Institute
A Mushroom Research Database for Scientists, Clinicians & Care-Givers.
Searchable Public Database
Published Works
Mushroom Research Institute
Date of Publication: July 2017
Keywords: Psilocybin; addiction; anxiety; cancer; depression; psychedelic.
Article Name: Potential Therapeutic Effects of Psilocybin
Description: Here, we review therapeutic research on psilocybin, the classic psychedelic that has been the focus of most recent research. For mood and anxiety disorders, three controlled trials have suggested that psilocybin may decrease symptoms of depression and anxiety in the context of cancer-related psychiatric distress for at least 6 months following a single acute administration.
Mushroom Research Institute
Date: February 2001
Keywords: LSD; MDMA; hallucinogens; ketamine; Psilocybin; psychedelics.
Article Name: Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine
Description: In this review, the pharmacology of hallucinogenic compounds is summarized by underscoring the differences between psychedelic and nonpsychedelic hallucinogens as well as entactogens, and their behavioral effects in both animals and humans are described.
Mushroom Research Institute
Date: May 2021
Keywords: addiction; anxiety; cancer; depression; magic mushrooms; neuropharmaceuticals; neurotherapeutics; Psilocybin; psychedelic; psychopharmacology.
Article Name: The Therapeutic Potential of Psilocybin
Description: This review will explore the potential of psilocybin in the treatment of neuropsychiatry-related conditions, examining recent advances as well as current research.
Mushroom Research Institute
Date: May 2016
Keywords: depression; magic mushrooms; neuropharmaceuticals; neurotherapeutics; Psilocybin; psychedelic; psychopharmacology.
Article Name: Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study
Description: This study provides preliminary support for the safety and efficacy of psilocybin for treatment-resistant depression and motivates further trials, with more rigorous designs, to better examine the therapeutic potential of this approach.
Mushroom Research Institute
Date: November 2017
Keywords: Serotonin, 5-HT2AR, Depression, Treatment-resistant depression, Psilocybin, Psychedelic, Mood, Hallucinogen, Psychotherapy
Article Name: Psilocybin with psychological support for treatment-resistant depression: six-month follow-up
Description: This review will explore the potential of psilocybin in the treatment of neuropsychiatry-related conditions, examining recent advances as well as current research.
Mushroom Research Institute
Date: December 2016
Keywords: Psilocybin, anxiety, cancer, depression, hallucinogen, mystical experience, symptom remission
Description: This randomized, double-blind, cross-over trial investigated the effects of a very low (placebo-like) dose (1 or 3 mg/70 kg) vs. a high dose (22 or 30 mg/70 kg) of psilocybin administered in counterbalanced sequence with 5 weeks between sessions and a 6-month follow-up.
Mushroom Research Institute
Date: October 2017
Keywords: Psilocybin, treatment-resistant depression, fMRI
Article Name: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms
Description: Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatment-resistant depression (TRD).
Mushroom Research Institute
Date: December 2016
Keywords: Psilocybin, anxiety, cancer, depression, mystical experience, psychedelic
Description: In this double-blind, placebo-controlled, crossover trial, 29 patients with cancer-related anxiety and depression were randomly assigned and received treatment with single-dose psilocybin (0.3 mg/kg) or niacin, both in conjunction with psychotherapy. The primary outcomes were anxiety and depression assessed between groups prior to the crossover at 7 weeks.
Mushroom Research Institute
Date: May 2021
Keywords: psilocybin-Assisted Therapy, psilocybin, major depressive disorder, mdd, psychedelic integration therapy, p.i.t., p.a.t.
Article Name: Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder:
Description: In this randomized clinical trial of 24 participants with major depressive disorder, participants who received immediate psilocybin-assisted therapy compared with delayed treatment showed improvement in blinded clinician rater–assessed depression severity and in self-reported secondary outcomes through the 1-month follow-up
Mushroom Research Institute
Date: date
Keywords: Hallucinogen, addiction, mystical experience, nicotine, psilocybin, psychedelic, smoking cessation,spirituality,tobacco
Article Name: Long-term follow-up of psilocybin-facilitated smoking cessation
Description: To assess long-term effects of a psilocybin-facilitated smoking cessation program at ≥12 months after psilocybin administration.
Mushroom Research Institute
Date: September 2020
Keywords: anxiety, clinical trials, depression, meta-analysis, psilocybin, systematic review
Article Name: Psilocybin in the Context of Life-Threatening Diseases
Description: The aim of this work was to perform a systematic review with meta-analysis of clinical trials to assess the therapeutic effects and safety of psilocybin on those medical conditions.
Mushroom Research Institute
Date: September 2021
Keywords: antidepressant therapy, depression, psilocin, psilocybin, review,
Article Name: Rediscovering Psilocybin as an Antidepressive Treatment Strategy
Description: With this review, we provide an overview of the current state of research on the potential mechanisms of psilocybin, its antidepressant potential, and the associated risks and adverse effects, to provide an update on a controversial topic discussed in psychopharmacology.
Mushroom Research Institute
Date: November 2018
Keywords: depression, personality, NEO‐PI‐R, Openness, psilocybin, psychedelic
Article Name: Effects of psilocybin therapy on personality structure
Description: Twenty patients with moderate or severe, unipolar, TRD received oral psilocybin (10 and 25 mg, one week apart) in a supportive setting. Personality was assessed at baseline and at 3‐month follow‐up using the Revised NEO Personality Inventory (NEO‐PI‐R), the subjective psilocybin experience with Altered State of Consciousness (ASC) scale, and depressive symptoms with QIDS‐SR16.
Mushroom Research Institute
Date: November 2018
Keywords: amygdala, depression, emotional processing, psilocybin, psychedelics, fMRI,
Article Name: Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression
Description: In this open-label study, 20 individuals diagnosed with moderate to severe, treatment-resistant depression, underwent two separate dosing sessions with psilocybin. Psychological support was provided before, during and after these sessions and 19 completed fMRI scans one week prior to the first session and one day after the second and last.
Mushroom Research Institute
Date: January 2021
Keywords: Functional connectivity,Serotonin,Dopamine,Resting-state,Mouse,
Article Name: Psilocybin exerts distinct effects on resting state networks associated with serotonin and dopamine
Description: In this study, we investigated the effects of psilocybin on FC across the entire brain with a view to investigate underlying mechanisms.
Mushroom Research Institute
Date: November 2018
Keywords: psilocybin, abuse potential, Controlled Substances Act, depression, anxiety, addiction
Article Name: The Abuse Potential of Medical Psilocybin According to 8 Factors of the Controlled Substances Act
Description: This review assesses the abuse potential of medically-administered psilocybin, following the structure of the 8 factors of the US Controlled Substances Act (CSA).
Mushroom Research Institute
Date: June 2017
Keywords: empathy, moral decision-making, psilocybin, serotonin, 5-HT2A/1A receptors
Article Name: Effect of Psilocybin on Empathy and Moral Decision-Making
Description: We investigated the acute effect of psilocybin (0.215 mg/kg p.o.) in healthy human subjects on different facets of empathy and hypothetical moral decision-making using the multifaceted empathy test (n=32) and the moral dilemma task (n=24).
Mushroom Research Institute
Date: April 2021
Keywords: depression, hallucination, hallucinogen, psychedelic, serotonin
Article Name: Antidepressant-like actions of psilocybin are independent of 5-HT2R activation in mice
Description: We therefore asked whether psilocybin would exert antidepressant-like responses in mice and, if so, whether these responses required 5-HT2AR activation.
Mushroom Research Institute
Date: February 2021
Keywords: anxiety, depression, obsessive-compulsive disorder, psilocybin, substance-related disorders
Article Name: What is the clinical evidence on psilocybin for the treatment of psychiatric disorders? A review.
Description: In this paper we performed a systematic review of the clinical trials conducted so far regarding the therapeutic effects of psilocybin on psychiatric disorders.
Mushroom Research Institute
Date: JUNE 2019
Keywords: medical research, target validation, drug development, emotion
Article Name: Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels
Description: We here report for the first time the relationship between intensity of psychedelic effects, cerebral 5-HT2AR occupancy and plasma levels of psilocin in humans.
Mushroom Research Institute
Date: March 2020
Keywords: depression, mindfulness meditation, psilocybin, psychedelics, review
Article Name: Possible Complementary Effects of Mindfulness Meditation and and Psilocybin in the Treatment of Depression
Description: Based on predefined search strings used in two online databases (PubMed and Google Scholar) 1129 articles were identified. After screening title and abstract for relevance related to the question, 82 articles were retained and 11 were added after reference list search, resulting in 93 articles included in the review. Findings show that MM and psilocybin exert similar effects on mood, social skills, and neuroplasticity; different effects were found on executive functioning, neural core networks, and neuroendocrine and neuroimmune system markers.
Mushroom Research Institute
Date: September 2020
Keywords: Psychedelics, Resting state, Serotonin 2A receptor, fMRI.
Description: We tested the hypothesis that psilocybin modulates claustrum function in humans.
Mushroom Research Institute
Date: September 2017
Keywords: anti-cancer, anti-diabetic, mushroom, cancer, microbiota, prebiotics,
Article Name: A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota
Description: Mushrooms act as a prebiotics to stimulate the growth of gut microbiota, conferring health benefits to the host. In the present review, we have summarized the beneficial activities of various mushrooms on gut microbiota via the inhibition of exogenous pathogens and, thus, improving the host health.
Mushroom Research Institute
Date: January 2015
Keywords: mushrooms, agaricus, lentinus, pleurotis, ganoderma, Huitlacoche,
Article Name: Edible mushrooms: improving human health and promoting quality life
Description: All together with a long history as food source, mushrooms are important for their healing capacities and properties in traditional medicine.As a result of these properties, some mushroom extracts are used to promote human health and are found as dietary supplements.
Mushroom Research Institute
Date: October 2021
Keywords: cancer risk, diet, dose-response, epidemiology, mushroom, observational studies
Article Name: Higher Mushroom Consumption Is Associated with Lower Risk of Cancer: A Systematic Review
Description: We thus conducted a systematic review and meta-analysis to assess the association between mushroom intake and risk of cancer at any site. The association between higher mushroom consumption and lower risk of cancer, particularly breast cancer, may indicate a potential protective role for mushrooms in the diet.
Mushroom Research Institute
Date: February 2022
Keywords: mushroom nutraceutical, nutraceutical, climate change, dietary supplements, functional foods, mushroom spawn, polysaccharide,
Article Name: Medicinal Mushrooms: Past, Present and Future
Description: This review examines the past, present and future of medicinal mushroom development including the two legs concept for the mushroom industry and the pyramid model summarizing the various human applications of mushrooms. It considers numerous issues the industry needs to address to exploit fully the opportunities presented by the continued increasing demand for medicinal mushrooms, and by the future overall expansion of the medicinal mushroom movement.
Mushroom Research Institute
Date: August 2018
Keywords: Bioactive compounds; Higher basidiomycetes; Medicinal mushrooms; Pharmacological activity; Polysaccharides
Article Name: Medicinal mushroom: boon for therapeutic applications
Description: The present review focuses on the comprehensive account of the medicinal properties of various medicinal mushrooms. This will further help the researchers to understand the metabolites and find other metabolites as well from the mushrooms which can be used for the potential development of the drugs to treat various life-threatening diseases.
Mushroom Research Institute
Date: October 2015
Keywords: Edible Mushrooms; Antioxidant;
Article Name: Medicinal Mushroom Extracts Possess Differential Antioxidant Activity and Cytotoxicity to Cancer Cells
Description: Extracts were analyzed for their antioxidant activities using the % DPPH (2,2-diphenyl-1-picrylhydrazylhydrate) scavenging activity method.
Mushroom Research Institute
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Mushroom Research Institute
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